윤성일 교수
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윤성일 교수

윤성일 (Sung-il Yoon) 교수님
윤성일 (Sung-il Yoon) 교수님
학력
  • 1996 서울대학교 학사 (미생물학)
  • 1998 서울대학교 석사 (미생물학)
  • 2006 University of Alabama at Birmingham 박사 (미생물학)
주요경력
  • 강원대학교 의생명과학대학 의생명융합학부 부교수 (2016. 3 ~ 현재)
  • 강원대학교 의생명과학대학 시스템면역과학과 조교수 (2012. 3 ~ 2016.2)
  • The Scripps Research Institute, Research associate (2007. 2 ~ 2012. 2)
  • University of Alabama at Birmingham, Post-doctoral fellow (2006. 8 ~ 2007. 2)
연구실적
학위논문
  • 박사학위논문: Structural and biophysical analysis of IL-10 receptor interactions with cellular and Epstein-Barr virus IL-10. 2006. University of Alabama at Birmingham.
  • 석사학위논문: Phylogenetic relationships of the Stereaceae and its related taxa inferred from sequence analysis of nuclear small subunit ribosomal DNA. 1998. 서울대학교
 
정기학술지
  • Song, W.S., Kim, J.H., Chi-Min Choi, Woo-Jong Lee, Yoon, S.I. (2019) TLR5 binding and activation by KMRC011, a flagellin-derived radiation countermeasure. Biochem Biophys Res Commun 508: 570-575
  • Kim, J.H., Namgung, B., Jeon, Y.J., Song, W.S., Lee, J., Kang, S.G.†, Yoon, S.I. † (2018) Helicobacter pylori flagellin: TLR5 evasion and fusion-based conversion into a TLR5 agonist. Biochem Biophys Res Commun 505: 872-878 †Joint corresponding authors
  • Ahn, H., Kim, J., Kang, S.G., Yoon, S.I., Ko, H.J., Kim, P.H., Hong, E.J., An, B.S., Lee, E., Lee, G.S. (2018) Mercury and arsenic attenuate canonical and non-canonical NLRP3 inflammasome activation. Scientific Reports 8: 13659
  • Hong, H.J., Kim, T.H., Song, W.S., Ko, H.J., Lee, G.S., Kang, S.G., Kim, P.H., Yoon, S.I. (2018) Crystal structure of FlgL and its implications for flagellar assembly. Scientific Reports 8: 14307
  • Han, H.J., Jang, Y.S., Seo, G.Y., Park, S.G., Kang, S.G., Yoon, S.I., Ko, H.J., Lee, G.S., Kim, P.H. (2018) Murine γδ T Cells Render B Cells Refractory to Commitment of IgA Isotype Switching. Immune Network 18: e25
  • Kwak, Y.M., Park, S.C., Na, H.W., Kang, S.G., Lee, G.S., Ko, H.J., Kim, P.H., Oh, B.C., Yoon, S.I. (2018) Crystal structure of the VanR transcription factor and the role of its unique α-helix in effector recognition. FEBS Journal 285: 3786–3800
  • Park, S.C., Lee, K.C., Yoon, S.I. (2018) Expression, purification, crystallization, and X-ray diffraction studies on a PadR-like protein from Bacillus cereus. Biodesign 6: 33-36
  • Namgung, B., Kim, J.H., Song, W.S., Yoon, S.I. (2018) Crystal structure of the hydroxylaminopurine resistance protein, YiiM, and its putative molybdenum cofactor-binding catalytic site. Scientific Reports 8: 3304
  • Kim, S.H., Yeon, Y.K., Lee, J.M., Chao, J.R., Lee, Y.J., Seo, Y.B., Sultan, M.T., Lee, O.J., Lee, J.S., Yoon, S.I., Hong, I.S., Khang, G., Lee, S.J., Yoo, J.J., Park, C.H. (2018) Precisely printable and biocompatible silk fibroin bioink for digital light processing 3D printing. Nature Communications 9: 1620
  • Kim, S.R., Song, J.H., Ahn, J.H., Lee, G.S., Ahn, H., Yoon, S.I., Kang, S.G., Kim, P.H., Jeon, S.M., Choi, E.J., Shin, S., Cha, Y., Cho, S., Kim, D.E., Chang, S.Y., Ko, H.J. (2018) Antiviral and anti-inflammatory activity of budesonide against human rhinovirus infection mediated via autophagy activation. Antiviral Research 151: 87-96
  • Ahn, H., Kang, S.G., Yoon, S.I., Kim, P.H., Kim, D., Lee, G.S. (2018) Poly-gamma-glutamic acid from Bacillus subtilis upregulates pro-inflammatory cytokines while inhibiting NLRP3, NLRC4 and AIM2 inflammasome activation. Cellular & Molecular Immunology 15: 111-119
  • Park, S.C., Kwak, Y.M., Song, W.S., Hong, M., Yoon, S.I. (2017) Structural basis of effector and operator recognition by the phenolic acid-responsive transcriptional regulator PadR. Nucleic Acids Research 45: 13080–13093
  • Seo, G.Y., Lee, J.M., Jang, Y.S., Kang, S.G., Yoon, S.I., Ko, H.J., Lee, G.S., Park, S.R., Nagler, C.R., Kim, P.H. (2017) Mechanism underlying the suppressor activity of retinoic acid on IL4-induced IgE synthesis and its physiological implication. Cellular Immunology 322: 49-55
  • Ahn, H., Kang, S.G., Yoon, S.I., Ko, H.J., Kim, P.H., Hong, E.J., An, B.S., Lee, E., Lee, G.S. (2017) Methylene blue inhibits NLRP3, NLRC4, AIM2, and non-canonical inflammasome activation. Scientific Reports 7: 12409
  • Cho, S.Y., Song, W.S., Hong, H.J., Lee, G.S., Kang, S.G., Ko. H.J., Kim, P.H., Yoon, S.I. (2017) Tetrameric structure of the flagellar cap protein FliD from Serratia marcescens. Biochem Biophys Res Commun 489: 63-69
  • Song, W.S., Cho, S.Y., Hong, H.J., Park, S.C., Yoon, S.I. (2017) Self-oligomerizing structure of the flagellar cap protein FliD and its implication in filament assembly. Journal of Molecular Biology 429: 847-857
  • Song, W.S., Jeon, Y.J., Namgung, B., Hong, M., Yoon, S.I. (2017) A conserved TLR5 binding and activation hot spot on flagellin. Scientific Reports 7: 40878
  • Lee, C., Kim, M.I., Park, J., Jeon, B.Y., Yoon, S.I. †, Hong, M.† (2017) Crystal structure of the flagellar chaperone FliS from Bacillus cereus and an invariant proline critical for FliS dimerization and flagellin recognition. Biochem Biophys Res Commun 487: 381-387
  • Ahn, H., Jeon, E., Kim, J.C., Kang, S.G., Yoon, S.I., Ko, H.J., Kim, P.H., Lee, G.S. (2017) Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production. Scientific Reports 7: 1314
  • Jeon, Y.J., Park, S.C., Song, W.S., Kim, O.H., Oh, B.C., Yoon, S.I. (2016) Structural and biochemical characterization of bacterial YpgQ protein reveals a metal-dependent nucleotide pyrophosphohydrolase. Journal of Structural Biology 195: 113-122
  • Park, S.C., Kim, P.H., Lee, G.S., Kang, S.G., Ko. H.J., Yoon, S.I. (2016) Structural and biochemical characterization of the Bacillus cereus 3-hydroxyisobutyrate dehydrogenase. Biochem Biophys Res Commun 474: 522-527
  • Lee, J.M., Jang, Y.S., Jin, B.R., Kim, S.J., Kim, H.J., Kwon, B.E., Ko, H.J., Yoon, S.I., Lee, G.S., Kim, W.S., Seo, G.Y., Kim, P.H. (2016) Retinoic acid enhances lactoferrin-induced IgA responses by increasing betaglycan expression. Cellular & Molecular Immunology 13: 862-870
  • Song, W.S., Yoon, S.I. (2016) Functional role of flagellin in bacterial flagellar assembly and immune receptor activation: structure and application. Biodesign 4:98-107
  • Kim, D.W., Lee, O.J., Kim, S.W., Ki, C.S., Chao, J.R., Yoo, H., Yoon, S.I., Lee. J.E., Park, Y.R., Kweon, H., Lee, K.G., Kaplan, D.L., Park, C.H. (2015) Novel fabrication of fluorescent silk utilized in biotechnological and medical applications. Biomaterials 70: 48-56
  • Song, W.S., Nam, M.S., Namgung, B., Yoon,S.I. (2015) Structural analysis of PseH, the Campylobacter jejuni N-acetyltransferase involved in bacterial O-linked glycosylation. Biochem Biophys Res Commun 458: 843-848
  • Jeon, Y. J., Song, W. S., Yoon, S. I. (2014) Purification, crystallization, and preliminary X-ray analysis of a putative nucleotide phosphohydrolase, YpgQ, from Bacillus subtilis. Acta Crystallogr Sect F Struct Biol Cryst Commun 70: 984-986
  • Park, S. C., Song, W. S., Yoon, S. I. (2014) Structural analysis of a putative SAM-dependent methyltransferase, YtqB, from Bacillus subtilis. Biochem Biophys Res Commun 446: 921-926
  • Park, S. C., Song, W. S., Wi, J., Yoon, S. I. (2014) Purification, crystallization, and X-ray crystallographic studies on a putative methyltransferase, YtqB, from Bacillus subtilis. Acta Crystallogr Sect F Struct Biol Cryst Commun 70: 482-484
  • Song, W.S., Yoon, S.I. (2014) Crystal structure of FliC flagellin from Pseudomonas aeruginosa and its implication in TLR5 binding and formation of the flagellar filament. Biochem Biophys Res Commun 444:109-115
  • Song, W. S., Hong, M., Yoon, S. I. (2014) Purification, crystallization and X-ray crystallographic studies on flagellin from Pseudomonas aeruginosa. Acta Crystallogr Sect F Struct Biol Cryst Commun 70: 200-202
  • Hong, M., Lee, P. S., Hoffman, R. M., Zhu, X., Krause, J. C., Laursen, N. S., Yoon, S. I., Song, L., Tussey, L., Crowe, J. E. Jr, Ward, A.B ., Wilson, I. A. (2013) Antibody Recognition of the Pandemic H1N1 Influenza Virus Hemagglutinin Receptor Binding Site. J Virol 87: 12471-12480.
  • Yoon, S. I., Kurnasov, O., Natarajan, V., Hong, M., Gudkov, A. V., Osterman, A. L., Wilson, A. I. (2012) Structural basis of TLR5-flagellin recognition and signaling. Science 335: 859-864
  • Hong, M.*, Yoon, S. I.*†, Wilson, A. I.† (2012) Recombinant expression of TLR5 proteins by ligand supplementation and a leucine-rich repeat hybrid technique. Biochem Biophys Res Commun 427: 119-124
    *Equal contribution
    †Joint corresponding authors
  • Yoon, S. I., Jones, B. C., Logsdon, N. J., Harris, B. D., Kuruganti, S., Walter, M. R. (2012) Epstein-Barr virus IL-10 engages IL-10R1 by a two-step mechanism leading to altered signaling properties. J Biol Chem 287: 26586-26595
  • Hong, M., Yoon, S. I., and Wilson, I. A. (2012) Structure and functional characterization of the RNA-binding element of the NLRX1 innate immune modulator. Immunity 36: 337-347
  • Ainge, G. D., Martin, W. J., Compton, B. J., Hayman C. M., Larsen, D. S., Yoon, S. I., Wilson, I. A., Harper, J. L., and Painter, G. F. (2011) Synthesis and Toll-like receptor 4 (TLR4) activity of phosphatidylinositol dimannoside analogues. J Med Chem 54: 7268-7279
  • Yoon, S. I., Hong, M., and Wilson, I. A. (2011) An unusual dimeric structure and assembly for TLR4 regulator RP105-MD-1. Nat Struct Mol Biol 18: 1028-1035
  • Yoon, S. I., Hong, M., Han, G. W., and Wilson, I. A. (2010) Crystal structure of soluble MD-1 and its interaction with lipid IVa. Proc Natl Acad Sci U S A 107: 10990-10995
  • Yoon, S. I., Jones, B. C., Logsdon, N. J., Harris, B. D., Deshpande, A., Radaeva, S., Halloran, B. A., Gao, B., and Walter, M. R. (2010) Structure and mechanism of receptor sharing by the IL-10R2 common chain. Structure 18: 638-648.
  • Nuara, A. A., Walter, L. J., Logsdon, N. J., Yoon, S. I., Jones, B. C., Schriewer, J. M., Buller, R. M., and Walter, M. R. (2008) Structure and mechanism of IFN-γ antagonism by an orthopoxvirus IFN-γ-binding protein. Proc Natl Acad Sci U S A 105: 1861-1866
  • Yoon, S. I. and Walter, M. R. (2007) Identification and characterization of a +1 frameshift observed during the expression of Epstein-Barr virus IL-10 in Escherichia coli. Protein Expr Purif 53: 132-137
  • Yoon, S. I., Logsdon, N. J, Sheikh, F., Donnelly R. P., and Walter, M. R. (2006) Conformational changes mediate Interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex. J Biol Chem 281: 35088-35096
  • Yoon, S. I., Jones, B. C., Logsdon, N. J., and Walter, M. R. (2005) Same structure, different function: crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain. Structure 13: 551-564
  • Yoon, S. I., Kim, S. Y., Lim, Y. W., and Jung, H. S. (2003) Phylogenetic evaluation of stereoid fungi. J Microbiol Biotechnol 13: 406-414
 
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