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Faculty

Cha, Sang-Hoon 교수님
Cha, Sang-HoonLaboratory
  • Major : Immunology
  • Research field : Antibody Engineering, Protein drug development
  • Phone : 82-33-250-8383
  • E-mail : chash@kangwon.ac.kr
Education
days academic ability
1982-1987 Kangwon National University, BS in Environmental Science
1988-1989 Montana State University, MS in Microbiology
1989-1993 University of California (Davis), Ph.D. in Immunology
Professional Experience
days career
1993-1995 Post-doc researcher, Internal Medicine, University of California (Davis)
1995-Present Professor, Department of Systems Immunology, Kangwon National University
2000-2012 CEO, IG Therapy Co.
2006-2007 Visiting Professor, Department of Pediatrics, National University of Singapore
2013-Present CEO, AprilBio Co
Publication
  • 1. 1993, Combinatorial autoantibodies to dihydrolipoamide acetyltransferase, the major autoantigen of primary biliary cirrhorsis, Proc. Natl. Acad. Sci. USA, 90, 2527-2531.
  • 2. 1994, Nucleotide Scquence Analysis of Nutral and Combinatorial Anti-PDC-E2 Antibodies in Patients with Primary Biliary, J. immunology, 152/, 577-2585.
  • 3. 1994, Heterogeneity of Combinatorial Human Autoantibodies Against PDC-E2 and Biliary Epithelial Cells in Patients with Primary Biliary Currhosis, Hepatology, 20, 584-591.
  • 4. 1994, Human Combinatorial Autoantibodies and Mouse Monoclonal Antibodies to PDC-E2 Produce Abnormal Apical Staining of Salivary Glands in Patients with Coexistent Primary Biliary Cirrhosis and Sjogren's Syndrome, Hepatology, 20, 574~583.
  • 5. 1995, Autoantibodies to BCOADC-E2 in patients with primary biliary cirrhosis recognize a conformational epitope, Hepatology, 22, 505~513.
  • 6. 1996, Random Phage mimotopes recognized by monoclonal antiboes against the pyruvate dehydrogenase complex-E2(PDC-E2), Proc. Natl. Acad. Sci. USA, 93, 10949-10954.
  • 7. 1996, Inhibition of PCD-E2 Human Combinatorial Autoantibodies by Peptide Mimotopes, Journal of Autoimmunity, 9, 785-793.
  • 8. 1998, Isolation of Human Anti-branched Chain α-Oxo acid Dehydrogenase-E2 Recombinant Antibodies by Ig Repertoire Cloning in Idiopathic Dilated Cardiomyopathy, Molecules and Cells, 9(1), 25-30.
  • 9, 1999, Isolation of rice allergenic cDNA clones from a rice cDNA library by immunoscreening with a polyclonal antibody specific to 16 kDa rice allergenic protein, Experimental &Molecular Medicine, 31(4), 185-190.
  • 10. 2000, Isolation of peptide ligands that inhibit glutamate racemase activity from a random phage display library, J. Biomolecular Screening, 5(6), 435-440.
  • 11. 2000, Effect of Glucose and Acetic Acid on the Growth of Recombinant E.coli and the Production of Pyruvate Dehydrogenase Complex E2 Specific Human Monoclonal Antibody, Korean J. Biotechnol. Bioeng., 15(5), 482-488.
  • 12. 2000, Product of Pyruvate Dehydrogenase Complex-E2 Specific Human Monoclonal Antibody in Fed-Batch Culture Systems with High Cell Density Recombinant Escherichia coli., Korean J. Biotechnol. Bioeng., 15(5), 489-496.
  • 13. 2001,Generation of a Murine Single Chain Fv (scFv) Antibody specific for Cucumber Mosaic Virus(CMV) Using a Phage Display Library, Molecules and Cells, 11(1), 7-12.
  • 14. 2002, An improved helper phage system for efficient isolation of specific antibody molecules in phage display, Nucleic Acids Research, 30(5), 5e18.
  • 15. 2002, Isolation of Human scFv Antibodies Specific for House Dust Mite Antigens from an Asthma Patient by Using a Phage Display Library, Immune Network, 2(2), 91-95.
  • 16. 2004, Isolation of two distinct population of recombinant antibody molecules specific for rat malonyl-CoA decarboxylase from a semi-synthetic human scFv display library using Ex-phage system, Immunology Letters, 91, 163-170.
  • 17. 2004, Isolation and characterization of Human scFv Molecules specific for Recombinant Human Heat Shock Protein (HSP) 70.1, Immune Network, 4(1), 7-16.
  • 18. 2007, On the influence of vector design on antibody phage display, J. Biotechnology, 127, 626-637.
  • 19. 2007, Enhancing phage display of antibody fragments using gIII-amber suppression, Gene, 386, 81-89.
  • 20. 2008. Establishment of a reliable dual-vector system for the phage display of antibody fragments, J. Immunological Methods, 333, 24-37.
  • 21. 2009, Successful Application of the Dual-vector System-II in Creating a Reliable Phage-displayed Combinatorial Fab Library, Mol &Cells, 27, 313.
  • 22. 2009, Methods for rapid identification of a functional single-chain variable fragment using alkaline phosphatase fusion, BMB reports, 42, 731.
  • 23. 2010, Expression of a functional zipFv antibody fragment and its fusion with alkaline phosphatase in the cytoplasmic of an Escherichia coli, Immune Network, 10, 35.
  • 24. 2010, Development of the dual-vector system-III (DVS-III), which facilitates affinity maturation of a Fab antibody via light chain shuffling, Immunology Letters, 132, 24.
  • 25. 2010, Isolation of a Human Anti-Epidermal Growth Factor Receptor Fab Antibody, EG-19-11, with Subnanomolar Affinity from Naïve Immunoglobulin Repertoires Using a Hierarchical Antibody Library System, 134, 55.
  • 26. 2011, Use of Ex12 helper phage improves quality of a phage-displayed antibody library by ameliorates the adverse effect of clonal variations, BMB Reports, 44(4) 244-249
  • 27. 2011, Isolation of human Fab antibodies specific for the low-affinity IgE receptor (CD23) by selecting a hierarchical antibody library system against B lymphoblastic IM-9 cells, Immunology Letters, 136, 213.
  • 28. 2011, Anti-inflammatory activity of ethanol extract derived from Phaseolus angularis beans, Journal of Ethnopharmacology, 137. 1197-1206
  • 29. 2011, Thrombin-induced Migration and Matrix Metalloproteinase-9 Expression Are Regulated by MAPK and PI3K Pathways in C6 Glioma Cells. Korean J Physiol Pharmacol. 15(4):211-216
  • 30. 2013, Involvement of Src and the actin cytoskeleton in the antitumorigenic action of adenosine dialdehyde, Biochemical Pharmacology, 85, 1042–1056
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