Our Lab focuses on the development of therapeutic antibodies for the treatment of cancers and HBV infection. Therapeutic antibodies are monoclonal antibodies that do not induce immune response in humans after repeated administration. They include humanized antibody and human monoclonal antibodies, which will be used for development of bispecific antibody and antibody-drug conjugate to improve their therapeutic efficacy for cancer therapy.
Major research areas
Functional significance of L1 cell adhesion molecule (L1CAM) in tumor progression of bile duct cancers
Development of human anti-L1CAM monoclonal antibodies for the treatment of cancers
Development of bispecific antibodies to improve therapeutic efficacy of cancer therapy
Development of humanized antibodies for the prevention and treatment of hepatitis B
Affinity maturation of therapeutic antibodies
Construction and production of therapeutic antibodies using mammalian cells