Structural Biology Lab.
Structural Biology Laboratory
- Biomedical Science building, Room A-201, A-209
- Sung-il Yoon, Ph.D.
- Lab website : https://sites.google.com/site/structurekangwon/
Our research aim is to determine 3-dimensional structures of biologically significant macromolecules at the atomic resolution using X-ray crystallography and to define their biological functions through structure-based biophysicochemical studies. We are particularly interested in revealing structural and molecular mechanisms for immune responses against pathogens as well as pathogenesis of infectious diseases.
Major research areas
- Structural and mechanistic studies on pathogen recognition by immune receptors
- Toll-like receptor 5 (TLR5) activation by bacterial flagellin
- Drug development of flagellin variants
- Structural basis of antigen recognition by therapeutic antibodies
- Structural studies on microbial pathogenesis focusing on virulence factors
- Structure-function studies on bacterial transcription factors and enzymes
- Enzymatic mechanism of methyltransferase, nucleotide hydrolase, and glycosyl transferase
- Gene regulation by transcription factors